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KMID : 0613820020120030332
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Journal of Life Science
2002 Volume.12 No. 3 p.332 ~ p.339
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Protective Mechanism of Flavonoids Isolated from Rhus verniciflua on the Biliary Liver Fibrosis in Rat
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Park Hee-Juhn
Lee Kyung-Tae
Park Kun-Young
Han Gab-Yi
Jung Min-Hwa
Choi Jong-Won
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Abstract
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The pathogenesis of cholestatic liver injury as well as the modulation of hepatic fibrogenesis is causally associated with involvement of reactive oxygen species and free radical reactions. In this study, we investigated whether flavonoids (fustin, sulfuretin) which were isolated from Rhus verniciflua Stokes (RCS) have antioxidant and antihepatotoxicity effect under the biliary liver fibrosis condition. After surgery (control) and posttreated RCS methanol extract (250mg/kg), ethyl acetate extract (250mg/kg) and flavonoids were administered p.o. 10mg/kg/day in two weeks for contol groups. The concentration of clinical parameters and product of hepatic lipid peroxidation and the hydroxyproline content were significantly increased in liver fibrosis developed rats. Among the clinical parameters of serum, value of ALT, AST, SDH, total bilirubin and γ-GT in posttreated RCS components-group showed significantly lower than in control-group. The content of hydroxyproline in posttreated RCS components- group showed lower than in control group and then the value of MDA in posttreated RCS components-group was also significantly reduced to 40～60% of that in control group. The hepatic xanthine oxidase and aldehyde oxidase activities were posttreated RCS components-group showed significantly lower than in control-group. The hepatic SOD and glutathione peroxidase activities were posttreated RCS components-group showed significantly higher than in control-group. Hence we concluded that acitive components of fustin and sulfuretin which were isolated from R. verniciflua Stokes were hepatoprotective effect in experimental liver fibrosis.
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KEYWORD
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fibrosis, fustin, sulfuretin, Rhus chinenesis, antihepatotoxicity
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